Developmental determinants at the mammalian optic chiasm

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Developmental determinants at the mammalian optic chiasm.

The mammalian optic chiasm is widely and properly regarded as a region where axons from the temporal retina take an uncrossed course and separate from axons arising in the nasal retina that take a crossed course. However, this is but a rough approximation of the adult situation, and developmental studies must take account of several distinctive stages and axon rearrangements that characterize t...

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During development of the mammalian CNS, axons encounter multiple pathway choices on their way to central target structures. A major pathway branch point in the visual system occurs at the optic chiasm, where retinal ganglion cell axons may either enter the ipsilateral or the contralateral optic tract. To investigate whether embryonic mouse retinal ganglion cell axons, upon reaching the optic c...

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ژورنال

عنوان ژورنال: The Journal of Neuroscience

سال: 1995

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.15-07-04727.1995